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KMID : 1134820070360121544
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 12 p.1544 ~ p.1552
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Effects of Isoflavone?Rich Bean Sprout on the Lipid Metabolism of the Ethanol?Treated Rats
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Kim Kwang-Ok
Lee Hye-Sung
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Abstract
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The present study evaluated the effects of isoflavone-rich bean sprout on the lipid metabolism in ethanol-treated rats. Fifty male Sprague-Dawley rats were randomly divided into five groups: normal control, alcohol control, low soybean sprout＋ethanol (low SS), high soybean sprout＋ethanol (high SS) and isoflavone extract ＋ethanol (IE). They were fed experimental diets based on Lieber-DeCarli liquid diet for 40 days. Body weight, food intake and feed efficiency ratio (FER) of ethanol-treated groups were significantly suppressed compared with that of the normal control group. Among the ethanol-treated groups, high SS group showed in significant increase in the body weight, food intake and FER. Supplementation of isoflavone-rich soybean sprout powder or isoflavone extract significantly decreased plasma triglyceride (TG), total cholesterol (TC), atherogenic index (AI) and increased the ratio of HDL-cholesterol to TC. Supplements also significantly decreased total lipid, TG and TC in liver tissue compared with that of alcohol control. There was a significant decrease in hepatic lipid peroxidation products in IE group compared with other ethanol-treated groups. This results suggest that supplementation of isoflavone-rich bean sprout powder may exert beneficial effects on lipid metabolism in chronically alcohol-treated animals by improving lipid profiles in plasma and liver tissues.
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KEYWORD
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isoflavone, soybean sprout, ethanol, lipid metabolism
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